p53 in stem cells
نویسندگان
چکیده
منابع مشابه
p53 and cancer stem cells
The role of p53 in the biology of mammary epithelial stem cells (SC) is well established. p53 may counteract SC expansion by several mechanisms, including restriction of self-renewing divisions and block of reprogramming of somatic/ progenitor cells into SCs. p53 regulates the polarity of cell division in mammary SCs. p53 is often inactivated by loss or mutation in breast cancer. This inactivat...
متن کاملTargeting cancer stem cells with p53 modulators
Cancer stem cells (CSC) typically over-express aldehyde dehydrogenase (ALDH). Thus, ALDHbright tumor cells represent targets for developing novel cancer prevention/treatment interventions. Loss of p53 function is a common genetic event during cancer development wherein small molecular weight compounds (SMWC) that restore p53 function and reverse tumor growth have been identified. Here, we focus...
متن کاملStem Cells in Glaucoma Management
Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...
متن کاملStem Cells in Regenerative Endodontics
Background Currently, clinical endodontics includes procedures that are based on the ability of stem cells to accomplish repair (eg, direct pulp capping, apexogenesis, apexification, and even pulpal regeneration). An attempt is made to critically assess the current status in pulp regeneration therapy. Methods: Systematically, 2 distinctly different strategies exist involving stem cells for t...
متن کاملAdipose Stem Cells as a Feeder Layer Reduce Apoptosis and p53 Gene Expression of Human Expanded Hematopoietic Stem Cells Derived from Cord Blood
Introduction: Human hematopoietic stem cells (hHSCs) have been used for transplantation in hematologic failures. Because the number of hHSCs per cord blood unit is limited, the expansion of these cells is important for clinical application. It has been reported that cytokines and feeder layer provide a perspective to in vitro expansion of hHSCs. In this regard, cord blood CD34+ cells ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Biological Chemistry
سال: 2011
ISSN: 1949-8454
DOI: 10.4331/wjbc.v2.i9.202